Lactobacillus pentosus Modulates Immune Response by Inducing IL-10 Producing Tr1 Cells
Immune Network
;
: 39-2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-785822
ABSTRACT
Several gut commensals have been shown to modulate host immune response. Recently, many food derived microbes have also been reported to affect the immune system. However, a mechanism to identify immunostimulatory and immunoregulatory microbes is needed. Here, we successfully established an in vitro screening system and identified an immunoregulatory bacterium, Lactobacillus pentosus KF340 (LP340), present in various fermented foods. LP340 induced a regulatory phenotype in mice Ag presenting cells which, in turn, induced IL-10 and IFN-γ producing Type 1 regulatory T cells (Tr1 cells) from naïve CD4⁺ T cells. Naïve CD4⁺ T cells co-cultured with LP340 treated dendritic cells highly expressed cytokine receptor IL-27R and were CD49b and lymphocyte-activation gene 3 double positive. Oral administration of LP340 in mice with atopic dermatitis reduced cellular infiltration in affected ear lobes and serum IgE levels, thus, ameliorating the disease symptoms. This suggests a systemic immunoregulatory effect of LP340. These findings demonstrate that LP340, a bacterium derived from food, prevents systemic inflammation through the induction of IL-10 producing Tr1 cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Técnicas In Vitro
/
Células Dendríticas
/
Imunoglobulina E
/
Linfócitos T
/
Programas de Rastreamento
/
Administração Oral
/
Interleucina-10
/
Linfócitos T Reguladores
/
Receptores de Citocinas
Tipo de estudo:
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Animais
Idioma:
Inglês
Revista:
Immune Network
Ano de publicação:
2019
Tipo de documento:
Artigo
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