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Noninvasive Biomarker for Predicting Treatment Response to Concurrent Chemoradiotherapy in Patients with Hepatocellular Carcinoma
Investigative Magnetic Resonance Imaging ; : 351-360, 2019.
Artigo em Inglês | WPRIM | ID: wpr-785880
ABSTRACT

PURPOSE:

To investigate noninvasive biomarkers for predicting treatment response in patients with locally advanced HCC who underwent concurrent chemoradiotherapy (CCRTx).MATERIALS AND

METHODS:

Thirty patients (55.5 ± 10.2 years old, MF = 246) who underwent CCRTx due to advanced HCC were enrolled. Contrast-enhanced US (CEUS) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) were obtained before and immediately after CCRTx. The third CEUS was obtained at one month after CCRTx was completed. Response was assessed at three months after CCRTx based on RECIST 1.1. Quantitative imaging biomarkers measured with CEUS and MRI were compared between groups. A cutoff value was calculated with ROC analysis. Overall survival (OS) was compared by the Breslow method.

RESULTS:

Twenty-five patients were categorized into the non-progression group and five patients were categorized into the progression group. Peak enhancement of the first CEUS before CCRTx (PE1) was significantly lower in the non-progression group (median, 18.6%; IQR, 20.9%) than that in the progression group (median, 59.1%; IQR, 13.5%; P = 0.002). There was no significant difference in other quantitative biomarkers between the two groups. On ROC analysis, with a cutoff value of 42.6% in PE1, the non-progression group was diagnosed with a sensitivity of 90.9% and a specificity of 100%. OS was also significantly longer in patients with PE1 < 42.6% (P = 0.014).

CONCLUSION:

Early treatment response and OS could be predicted by PE on CEUS before CCRTx in patients with HCC.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Imageamento por Ressonância Magnética / Biomarcadores / Curva ROC / Ultrassonografia / Sensibilidade e Especificidade / Carcinoma Hepatocelular / Imagem de Perfusão / Quimiorradioterapia / Critérios de Avaliação de Resposta em Tumores Sólidos / Métodos Tipo de estudo: Estudo diagnóstico / Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Investigative Magnetic Resonance Imaging Ano de publicação: 2019 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Imageamento por Ressonância Magnética / Biomarcadores / Curva ROC / Ultrassonografia / Sensibilidade e Especificidade / Carcinoma Hepatocelular / Imagem de Perfusão / Quimiorradioterapia / Critérios de Avaliação de Resposta em Tumores Sólidos / Métodos Tipo de estudo: Estudo diagnóstico / Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Investigative Magnetic Resonance Imaging Ano de publicação: 2019 Tipo de documento: Artigo