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MicroRNA-374a Expression as a Prognostic Biomarker in Lung Adenocarcinoma
Journal of Pathology and Translational Medicine ; : 354-360, 2019.
Artigo em Inglês | WPRIM | ID: wpr-786130
ABSTRACT

BACKGROUND:

Lung cancer is the most common cause of cancer-related death, and adenocarcinoma is the most common histologic subtype. MicroRNA is a small non-coding RNA that inhibits multiple target gene expression at the post-transcriptional level and is commonly dysregulated in malignant tumors. The purpose of this study was to analyze the expression of microRNA-374a (miR-374a) in lung adenocarcinoma and correlate its expression with various clinicopathological characteristics.

METHODS:

The expression level of miR-374a was measured in 111 formalin-fixed paraffin-embedded lung adenocarcinoma tissues using reverse transcription-quantitative polymerase chain reaction assays. The correlation between miR-374a expression and clinicopathological parameters, including clinical outcome, was further analyzed.

RESULTS:

High miR-374 expression was correlated with advanced pT category (chi-square test, p=.004) and pleural invasion (chi-square test, p=.034). Survival analysis revealed that patients with high miR-374a expression had significantly shorter disease-free survival relative to those with low miR-374a expression (log-rank test, p=.032).

CONCLUSIONS:

miR-374a expression may serve as a potential prognostic biomarker for predicting recurrence in early stage lung adenocarcinoma after curative surgery.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Recidiva / Adenocarcinoma / Expressão Gênica / Reação em Cadeia da Polimerase / Intervalo Livre de Doença / MicroRNAs / Pequeno RNA não Traduzido / Pulmão / Neoplasias Pulmonares Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Journal of Pathology and Translational Medicine Ano de publicação: 2019 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Recidiva / Adenocarcinoma / Expressão Gênica / Reação em Cadeia da Polimerase / Intervalo Livre de Doença / MicroRNAs / Pequeno RNA não Traduzido / Pulmão / Neoplasias Pulmonares Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Journal of Pathology and Translational Medicine Ano de publicação: 2019 Tipo de documento: Artigo