Lichen Planus Developed During the Treatment with Nivolumab in a Patient with Lung Cancer: A Case Report and Literature Review / 대한피부과학회지
Korean Journal of Dermatology
; : 551-555, 2019.
Article
em En
| WPRIM
| ID: wpr-786276
Biblioteca responsável:
WPRO
ABSTRACT
Nivolumab is a fully-humanized IgG4 monoclonal antibody that competitively binds to the programmed cell death receptor-1 protein (an immune check-point molecule) present on activated T cells. Nivolumab is approved for the treatment of advanced melanoma, lung cancer, and renal cell carcinoma. It attenuates the inactivation of cytotoxic CD8+ T cells and, produces an antitumor effect; however it may be associated with immune-related adverse events, including the development of lichen planus (LP). A 72-year-old man presented with a 2-month history of multiple, polygonal, purplish papules on the dorsal aspect of both hands. He was diagnosed with large cell neuroendocrine carcinoma (LCNEC) of the lung 4 years earlier and was treated with nivolumab (3 mg/kg every 2 weeks) for 9 months. By the 14th course of nivolumab therapy, the patient developed multiple rashes on the dorsal aspect of both hands, and biopsy was consistent with findings of LP. We report a rare case of LP in a patient with lung cancer treated with nivolumab.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Biópsia
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Imunoglobulina G
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Carcinoma de Células Renais
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Linfócitos T
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Morte Celular
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Carcinoma Neuroendócrino
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Exantema
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Mãos
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Líquen Plano
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Líquens
Limite:
Aged
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Humans
Idioma:
En
Revista:
Korean Journal of Dermatology
Ano de publicação:
2019
Tipo de documento:
Article