Generalized Osteoporosis in Korean Rheumatoid Arthritis Patients / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 32-42, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-78649
ABSTRACT
OBJECTIVES:
To assess the extent of generalized osteoporosis in Korean rheumatoid arthritis patients and evaluate the importance of disease activity, duration of disease, menopausal status, corticosteroid use and markers of bone metabolism.METHODS:
Bone mineral density was measured by dual energy x-ray absorptiometry (DEXA) at 3 locations in 134 rheumatoid arthritis patients, aged 21~80 (57 premenopausal and 66 postmenopausal patients). Markers of bone metabolism were measured and assessed in relation to the disease activity and corticosteroid use.RESULTS:
The mean age of the study population was 49 years and mean age of the menopause was 48.1+/-3.6 years. Decreased bone mineral density was observed at all 3 locations measured in the study population (Z-score -0.36, -0.14 and -0.66 for BMD of L-spine, femoral neck and femur Ward? triangle respectively). Fifty nine percent of the patients showed osteopenia (T-score <-1) and 13.4% showed T-score lower than -2.5. The best independent predictors of bone mass (stepweise multiple regression analysis) was body mass index, cortocosteroid use, and CRP in premenopausal patients and years post menopause, age, alkaline phosphatase and rheumatoid factor in postmenopausal patients. Urinary excretion of deoxypyridinoline was increased in both pre- and postmonopausal RA patients while serum osteocalcin level was normal in both groups. Deoxypyridinoline level was significantly correlated with CRP in premenopausal RA patients.CONCLUSION:
Generalized osteoporosis is also prevalent in Korean rheumatoid arthritis patients. Bone metabolism appears to be uncoupled. Deoxypyridinoline correlated best with CRP and thus can provide a rational approach for selecting and treating patients with RA to reduce the risk of osteoporotic fracture.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoporose
/
Artrite Reumatoide
/
Fator Reumatoide
/
Doenças Ósseas Metabólicas
/
Menopausa
/
Absorciometria de Fóton
/
Índice de Massa Corporal
/
Densidade Óssea
/
Osteocalcina
/
Pós-Menopausa
Tipo de estudo:
Estudo prognóstico
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
The Journal of the Korean Rheumatism Association
Ano de publicação:
2000
Tipo de documento:
Artigo
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