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Refractory Peptic Ulcer Disease
The Korean Journal of Helicobacter and Upper Gastrointestinal Research ; : 5-9, 2019.
Artigo em Coreano | WPRIM | ID: wpr-786613
ABSTRACT
The eradication of Helicobacter pylori and the widespread use of effective antisecretory therapies, including proton pump inhibitors, have improved the management of peptic ulcer disease. However, in some patients, peptic ulcer disease is refractory to 8 to 12 weeks of standard antisecretory drug treatment. For refractory peptic ulcer disease, further evaluation of the risk factors and causes of refractory peptic ulcer disease, including patient risk factors and noncompliance (smoking, nonsteroidal anti-inflammatory drug use, and noncompliance with medical treatment), persistent H. pylori infection, and non-H. pylori-related factors (giant ulcer, gastrinoma, infections other than H. pylori, and malignancy), is essential. The treatment should focus on the cause of the refractory peptic ulcer disease, avoiding smoking and nonsteroidal anti-inflammatory drug, the treatment of persistent H. pylori, use of high-dose proton pump inhibitors, or surgical excision of gastrinomas. Surgery should be considered in patients who are at high risk for complications and recurrent peptic ulcer disease despite medical treatment. In this review, I describe the diagnosis and treatment of refractory peptic ulcer disease.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Úlcera Péptica / Fumaça / Úlcera / Gastrinoma / Fumar / Anti-Inflamatórios não Esteroides / Fatores de Risco / Helicobacter pylori / Diagnóstico / Inibidores da Bomba de Prótons Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Fatores de risco Limite: Humanos Idioma: Coreano Revista: The Korean Journal of Helicobacter and Upper Gastrointestinal Research Ano de publicação: 2019 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Úlcera Péptica / Fumaça / Úlcera / Gastrinoma / Fumar / Anti-Inflamatórios não Esteroides / Fatores de Risco / Helicobacter pylori / Diagnóstico / Inibidores da Bomba de Prótons Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Fatores de risco Limite: Humanos Idioma: Coreano Revista: The Korean Journal of Helicobacter and Upper Gastrointestinal Research Ano de publicação: 2019 Tipo de documento: Artigo