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The problem of medicating women like the men: conceptual discussion of menstrual cycle-dependent psychopharmacology
Translational and Clinical Pharmacology ; : 127-133, 2019.
Artigo em Inglês | WPRIM | ID: wpr-786682
ABSTRACT
While hormonal changes during the ovulatory cycles affect multiple body systems, medical management, including medication dosing remains largely uniform between the sexes. Little is known about sex-specific pharmacology in women. Although hormonal fluctuations of the normal menstruating process alters women's physiology and brain biochemistry, medication dosing does not consider such cyclical changes. Using schizophrenia as an example, this paper illustrates how a woman's clinical symptoms can change throughout the ovulatory cycle, leading to fluctuations in medication responses. Effects of sex steroids on the brain, clinical pharmacology are discussed. Effective medication dose may be different at different phases of the menstrual cycle. Further research is needed to better understand optimal treatment strategies in reproductive women; we present a potential clinical trial design for examining optimal medication dosing strategies for conditions that have menstruation related clinical fluctuations.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Farmacologia Clínica / Fisiologia / Psicofarmacologia / Esquizofrenia / Esteroides / Bioquímica / Encéfalo / Vestuário / Ciclo Menstrual Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Translational and Clinical Pharmacology Ano de publicação: 2019 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Farmacologia Clínica / Fisiologia / Psicofarmacologia / Esquizofrenia / Esteroides / Bioquímica / Encéfalo / Vestuário / Ciclo Menstrual Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Translational and Clinical Pharmacology Ano de publicação: 2019 Tipo de documento: Artigo