Elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research
Translational and Clinical Pharmacology
; : 119-122, 2019.
Article
em En
| WPRIM
| ID: wpr-786684
Biblioteca responsável:
WPRO
ABSTRACT
In the conventional concept of translational research, investigations flow from the laboratory bench to the bedside. However, clinical research can also serve as the starting point for subsequent laboratory investigations that then lead back to the bedside. This article chronicles the evolution of a series of studies in which a detailed analysis of pharmacokinetics in hemodialysis patients revealed new physiological insight that, through a systems approach incorporating kinetic, physicochemical, physiologic, and clinical trial results, led to an elucidation of the pathophysiology of intradialytic skeletal muscle cramps. Based on this understanding, a therapeutic path forward is proposed.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Sistema Renina-Angiotensina
/
Sistema Nervoso Simpático
/
Análise de Sistemas
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Farmacocinética
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Diálise Renal
/
Músculo Esquelético
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Pesquisa Translacional Biomédica
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Cãibra Muscular
Limite:
Humans
Idioma:
En
Revista:
Translational and Clinical Pharmacology
Ano de publicação:
2019
Tipo de documento:
Article