Asymptomatic Middle East Respiratory Syndrome coronavirus infection using a serologic survey in Korea / 한국역학회지
Epidemiology and Health
; : 2018014-2018.
Article
em En
| WPRIM
| ID: wpr-786859
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES: The rates of asymptomatic infection with Middle East Respiratory Syndrome (MERS) coronavirus vary. A serologic study was conducted to determine the asymptomatic MERS infection rate in healthcare workers and non-healthcare workers by exposure status.METHODS: Study participants were selected from contacts of MERS patients based on a priority system in 4 regions strongly affected by the 2015 MERS outbreak. A sero-epidemiological survey was performed in 1,610 contacts (average duration from exposure to test, 4.8 months), and the collected sera were tested using an enzyme-linked immunespecific assay (ELISA), immunofluorescence assay (IFA), and plaque reduction neutralization antibody test (PRNT). Among the 1,610 contacts, there were 7 ELISA-positive cases, of which 1 exhibited positive IFA and PRNT results.RESULTS: The asymptomatic infection rate was 0.060% (95% confidence interval, 0.002 to 0.346). The asymptomatic MERS case was a patient who had been hospitalized with patient zero on the same floor of the hospital at the same time. The case was quarantined at home for 2 weeks after discharge, and had underlying diseases, including hypertension, angina, and degenerative arthritis.CONCLUSIONS: The asymptomatic infection was acquired via healthcare-associated transmission. Thus, it is necessary to extend serologic studies to include inpatient contacts who have no symptoms.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Osteoartrite
/
Infecção Hospitalar
/
Epidemiologia
/
Imunofluorescência
/
Infecções por Coronavirus
/
Coronavirus
/
Atenção à Saúde
/
Infecções Assintomáticas
/
Coronavírus da Síndrome Respiratória do Oriente Médio
/
Hipertensão
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Epidemiology and Health
Ano de publicação:
2018
Tipo de documento:
Article