A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using ¹¹CPK11195 / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
;
: 224-228, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-786988
ABSTRACT
PURPOSE:
Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo.METHODS:
Ten adult male Fischer F344 rats underwent [¹¹C]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [¹¹C]PK11195 between before and after injection was determined.RESULTS:
There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas.CONCLUSIONS:
Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [¹¹C]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [¹¹C]PK11195 PET would clarify the relationships between neuroinflammation and depression.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ratos Endogâmicos F344
/
Encéfalo
/
Lipopolissacarídeos
/
Neuroglia
/
Tomografia por Emissão de Pósitrons
/
Depressão
/
Elétrons
/
Imunidade Inata
/
Injeções Intraperitoneais
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Korean Journal of Nuclear Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
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