Role of Positron Emission Tomography as a Biologic Marker in the Diagnosis of Primary Progressive Aphasia: Two Case Reports / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
;
: 384-388, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-787009
ABSTRACT
Primary progressive aphasia (PPA) is a heterogenous neurodegenerative disorder characterized by declining language and speech ability. Various underlying neuropathologies can induce PPA, and the disorder is divided into three subtypes—progressive non-fluent aphasia, semantic variant aphasia, and logopenic aphasia—according to clinical features. Accurate disease classification and prediction of underlying diseases are necessary for appropriate treatment, but proper use of imaging tests is important because clinical information alone often makes it difficult to make accurate decisions. Because there is a characteristic metabolic pattern according to the subtypes, F-18 fluorodeoxyglucose positron emission tomography (PET) can indicate subtype classification. In addition, PETstudies for imaging amyloid or dopamine transporters play an important role in demonstrating underlying disease. The present case showed that PET imaging studies are useful in diagnosis and could be used as a biomarker in PPA.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Afasia
/
Biomarcadores
/
Dopamina
/
Classificação
/
Afasia Primária Progressiva
/
Doenças Neurodegenerativas
/
Tomografia por Emissão de Pósitrons
/
Diagnóstico
/
Elétrons
/
Proteínas da Membrana Plasmática de Transporte de Dopamina
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Korean Journal of Nuclear Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
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