Effect of Sodium Cromoglycate on Acetic Acid-induced Ulcerative Colitis in Mice / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 39-45, 2020.
Artigo
em Inglês
| WPRIM
| ID: wpr-787235
ABSTRACT
BACKGROUND/AIMS:
Ulcerative colitis (UC) is a type of inflammatory bowel disease that mainly involves the colon. Thus far, glucocorticoids and amino-salicylate have been the main treatment.METHODS:
To assess drugs with fewer side effects, this study evaluated the effects of sodium cromoglycate (SCG) on acetic acid-induced UC in rats. The treatment groups included SCG receivers (50 and 100 mg/kg, intra-orally) and sulfasalazine (SSZ) receivers (100 mg/kg, intra-orally). The colonic mucosal injury was assessed by clinical, macroscopic, and histopathological examinations.RESULTS:
In the treatment groups with 50 and 100 mg/kg of SCG, the clinical activity score decreased to 2.67±0.18 and 1.73±0.21 (p<0.05), respectively, compared to the UC control group (3.21±0.31), and were higher than that of the group given the standard treatment of 100 mg/kg SSZ (1.10±0.09). The treatment groups with 50 and 100 mg/kg of SCG showed a lower clinical gross lesion score than the UC control group (2.91±0.28 and 2.10±0.43, vs. 4.49±0.61, p<0.05) and were higher than the standard group (0.95±0.18). Treatment with SCG (100 mg/kg) decreased the macroscopic scores significantly compared to the UC control group (p<0.05) on the 8th day.CONCLUSIONS:
SCG (100mg/kg) decreased significantly the clinical activity score, gross lesion, and percentage-affected area compared to the UC controls on the 8th day.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sulfassalazina
/
Sódio
/
Úlcera
/
Doenças Inflamatórias Intestinais
/
Colite Ulcerativa
/
Cromolina Sódica
/
Colo
/
Ácido Acético
/
Glucocorticoides
Limite:
Animais
Idioma:
Inglês
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2020
Tipo de documento:
Artigo
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