A Case of 47-Years-Old Female with Obstructive Jaundice and Weight Loss / 대한소화기암학회지
Journal of Digestive Cancer Report
;
(2): 18-21, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-787284
ABSTRACT
Serine protease inhibitor Kazal-type 1 (SPINK1) is a gene expressed from pancreatic acinar cell which its mutation is known to be associated with chronic pancreatitis (CP) and pancreatic cancer. We report a case of a 47-years-old female with nausea and weight loss with yellow discoloration of skin. Initial imaging and endoscopic study led us to an impression of chronic pancreatitis with pancreatic cancer with common bile-duct dilation. Biopsy result was confirmed with pancreatic adenocarcinoma and additional imaging revealed lymph node and bone metastasis. Our genetic analysis revealed 194+2T>C mutation of SPINK1. Biliary obstruction was successfully decompressed by stent insertion and underwent chemotherapy and radiotherapy. Although there is accumulating evidence of association between SPINK1 mutation and CP, the relationship between SPINK1 mutation and pancreatic cancer in CP patient is an emerging concept. Genetic analysis should be considered in patients with young age especially when diagnosed with both CP and pancreatic cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Pancreáticas
/
Radioterapia
/
Pele
/
Biópsia
/
Adenocarcinoma
/
Redução de Peso
/
Stents
/
Genes vif
/
Icterícia Obstrutiva
/
Tratamento Farmacológico
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Journal of Digestive Cancer Report
Ano de publicação:
2019
Tipo de documento:
Artigo
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