The Association of Plasma Inflammatory Cytokines with Dementia and Mild Cognitive Impairment / 생물치료정신의학
Journal of the Korean Society of Biological Therapies in Psychiatry
;
(3): 28-35, 2019.
Artigo
em Coreano
| WPRIM
| ID: wpr-787401
ABSTRACT
OBJECTIVES:
The aim of this study was to investigate the association of plasma levels of inflammatory cytokines with dementia and mild cognitive impairment.METHODS:
We compared serum levels of tumor necrosis factor-alpha(TNF-alpha), interleukin-6(IL-6), and insulin-like growth factor-1(IGF-I) in patients with dementia(n=8), mild cognitive impairment(MCI, n=15) and normal elderly (n=14). The diagnosis of dementia was made by the Diagnostic Statistical Manual of Mental Disorders-4th edition (DSM-IV). MCI was diagnosed based on the criteria of the National Institute of Aging and Alzheimer Association(NIA-AA) working group.RESULTS:
When compared with normal controls, the levels of TNF-alpha and IL-6 were increased and level of IGF-I was decreased in MCI and dementia. Higher levels of TNF-alpha and IL-6 and lower level of IGF-I were also associated with increased age. However, when adjusted for age, the association between diagnosis and TNF-alpha, Il-6 and IGF-I was not significant.CONCLUSION:
The difference in plasma levels of inflammatory cytokines in dementia and MCI may be associated with aging.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Envelhecimento
/
Fator de Crescimento Insulin-Like I
/
Citocinas
/
Interleucina-6
/
Fator de Necrose Tumoral alfa
/
Demência
/
Diagnóstico
/
Disfunção Cognitiva
/
Necrose
Tipo de estudo:
Estudo diagnóstico
/
Guia de Prática Clínica
Limite:
Idoso
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Society of Biological Therapies in Psychiatry
Ano de publicação:
2019
Tipo de documento:
Artigo
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