Effect of Amyloid Deposition in PET on Hippocampal Metabolism in Amnestic-Mild Cognitive Impairment : Pilot Study / 생물치료정신의학
Journal of the Korean Society of Biological Therapies in Psychiatry
;
(3): 251-256, 2019.
Artigo
em Coreano
| WPRIM
| ID: wpr-787411
ABSTRACT
OBJECTIVES:
Most studies of hippocampal metabolism(HM) in amnestic mild cognitive impairment(aMCI) gave inconsistent results. Our objective was to evaluate the effect of amyloid-beta(Aβ) status on hippocampal metabolism in aMCI.METHODS:
Overall, 23 aMCI underwent three-dimensional magnetic resonance imaging(MRI), ¹⁸F-fluorodeoxyglucose-positron emission tomography(¹⁸FDG-PET) and ¹⁸F-Fluorbetaben amyloid positron emission tomography (amyloid-PET). According to Aβ status on amyloid PET, 23 aMCI were classified as either Aβ+aMCI(N=13) or Aβ−aMCI(N=10). The primary outcome was HM using ¹⁸FDG-PET and we investigate the difference on HM between Aβ+aMCI and Aβ−aMCI using analysis of variance(ANOVA) model, after controlling hippocampal volume.RESULTS:
We found that HM was more decreased in Aβ+aMCI than Aβ−aMCI. This result was not changed after controlling hippocampal volume.CONCLUSION:
Our findings suggest that Aβ+ is associated with decreased HM, regardless of hippocampal volume, in aMCI.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Projetos Piloto
/
Transtornos Cognitivos
/
Placa Amiloide
/
Tomografia por Emissão de Pósitrons
/
Amiloide
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Idioma:
Coreano
Revista:
Journal of the Korean Society of Biological Therapies in Psychiatry
Ano de publicação:
2019
Tipo de documento:
Artigo
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