Effects of postconditioning with N,N,N'N'-tetrakis-2-pyridylmethyl-ethylenediamine in isolated rat hearts / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 290-295, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-78792
ABSTRACT
BACKGROUND:
It was reported that N,N,N'N'-tetrakis-[2-pyridylmethyl]-ethylenediamine (TPEN), a transition metal chelator, confers cardioprotection against myocardial ischemic injury. In this study, we investigated the effect of TPEN targeting reperfusion period in isolated rat hearts.METHODS:
Langendorff perfused rat hearts were subjected to 30 min of regional ischemia and 2 h of reperfusion. Hearts were randomly assigned to either control (n = 9) or 10 micrometer of TPEN (n = 8) groups. TPEN was perfused for a period of 5 min before and 30 min after reperfusion.RESULTS:
The ratio of infarct area/ischemic area (AN/AR) was significantly reduced in TPEN treated hearts (6.9 +/- 1.7%, P 0.05).CONCLUSIONS:
Pharmacological postconditioning with TPEN reduces myocardial infarction however, TPEN does not modify post-ischemic systolic dysfunction in isolated rat hearts.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Reperfusão
/
Traumatismo por Reperfusão
/
Miocárdio Atordoado
/
Etilenodiaminas
/
Coração
/
Isquemia
/
Infarto do Miocárdio
Limite:
Animais
Idioma:
Inglês
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2010
Tipo de documento:
Artigo
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