Carcinoembryonic antigen levels of tumor-draining venous blood as a prognostic marker in colon cancer
Korean Journal of Clinical Oncology
;
(2): 68-74, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-788018
ABSTRACT
PURPOSE:
Carcinoembryonic antigen (CEA) is a tumor marker for colorectal cancer (CRC) related to recurrence and prognosis. We examined the ability of the CEA level measured directly from a tumor drainage vein (dCEA) to predict the prognosis of CRC more accurately than those from a peripheral vein (pCEA).METHODS:
Fifty-two patients who received curative resection for colon adenocarcinoma were enrolled. The patients were categorized into two groups according to normal pCEA ( < 5.9425 ng/mL, n=24) or elevated pCEA levels (≥5.9425 ng/mL, n=28). Blood was sampled at the time of surgery simultaneously from the tumor drainage vein and from the peripheral vein.RESULTS:
The clinicopathologic variables showed no significant difference between the two groups. Patients with dCEA levels < 20.192 ng/mL showed better disease-free (P=0.009) and overall survival (P=0.033) curves than those with dCEA levels ≥20.192 ng/mL. Elevated dCEA levels were a significant prognostic factor for overall survival and disease-free survival in Cox proportional hazard model analysis (hazard ratio [HR]=399; 95% confidence interval [CI], 16.4–9,747; P < 0.001; HR=9.39, 95% CI, 1.29–68.006; P=0.026). In subgroup analysis, we compared the data of normal range of dCEA group and elevated dCEA group with normal pCEA; the overall survival rate of patients with normal dCEA was better and the disease-free survival rate was significantly better (P=0.003).CONCLUSION:
CEA levels from a tumor drainage vein can be used as more accurate prognostic markers than levels from a peripheral vein in patients with colon cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Recidiva
/
Valores de Referência
/
Veias
/
Neoplasias Colorretais
/
Adenocarcinoma
/
Antígeno Carcinoembrionário
/
Modelos de Riscos Proporcionais
/
Drenagem
/
Taxa de Sobrevida
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Clinical Oncology
Ano de publicação:
2017
Tipo de documento:
Artigo
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