Time Point Expression of Apoptosis Regulatory Proteins in a Photochemically-Induced Focal Cerebral Ischemic Rat Brain / 전남의대학술지
Chonnam Medical Journal
;
: 144-149, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-788218
ABSTRACT
Apoptosis after global or focal cerebral ischemia plays a crucial role in mediating cell death. In this study, we observed the time point expression of physiologic events involving apoptosis regulatory proteins after photochemically-induced focal cerebral ischemia in Sprague-Dawley rats. Protein expression was evaluated at days 1, 3, and 7 by Western blot. Bcl-2, Bax, caspase-3, and phosphorylated Akt (pAkt) activity markedly increased in the ischemic hemisphere in a time-dependent manner, not affected. The expression of Bcl-2, Bax, and caspase-3 was dramatically changed around day 3, whereas changes in pAkt expression occurred at day 1. Differential elevation of these apoptosis regulatory proteins at various time points indicates that different modes of cell death occur in photochemically-induced focal cerebral ischemia in a rat brain.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Rosa Bengala
/
Encéfalo
/
Isquemia Encefálica
/
Western Blotting
/
Negociação
/
Morte Celular
/
Ratos Sprague-Dawley
/
Apoptose
/
Proteínas Reguladoras de Apoptose
/
Caspase 3
Limite:
Animais
Idioma:
Inglês
Revista:
Chonnam Medical Journal
Ano de publicação:
2011
Tipo de documento:
Artigo
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