Molecular Mechanisms Involved in Depotentiation and Their Relevance to Schizophrenia / 전남의대학술지
Chonnam Medical Journal
; : 1-6, 2012.
Article
em En
| WPRIM
| ID: wpr-788233
Biblioteca responsável:
WPRO
ABSTRACT
Long-term potentiation (LTP) and long-term depression (LTD) of synaptic transmission are forms of synaptic plasticity that have been studied extensively and are thought to contribute to learning and memory. The reversal of LTP, known as depotentiation (DP) has received far less attention however, and its role in behavior is also far from clear. Recently, deficits in depotentiation have been observed in models of schizophrenia, suggesting that a greater understanding of this form of synaptic plasticity may help reveal the physiological alterations that underlie symptoms experienced by patients. This review therefore seeks to summarize the current state of knowledge on DP, and then put the deficits in DP in models of disease into this context.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Plásticos
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Esquizofrenia
/
Potenciação de Longa Duração
/
Transmissão Sináptica
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Depressão Sináptica de Longo Prazo
/
Depressão
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Aprendizagem
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Memória
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Plasticidade Neuronal
Limite:
Humans
Idioma:
En
Revista:
Chonnam Medical Journal
Ano de publicação:
2012
Tipo de documento:
Article