Clinical Significance of MET Gene Copy Number in Patients with Curatively Resected Gastric Cancer / 전남의대학술지
Chonnam Medical Journal
;
: 81-85, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-788313
ABSTRACT
The present study analyzed the prognostic impact of MET gene copy number in patients with curatively resected gastric cancer who received a combination regimen of cisplatin and S-1. The MET gene copy number was analyzed by use of quantitative real-time polymerase chain reaction. From January 2006 to July 2010, 70 tumor samples from 74 patients enrolled in a pilot study were analyzed. According to a cutoff MET gene copy number of > or =2 copies, a high MET gene copy number was observed in 38 patients (54.3%). The characteristics of the 2 groups divided according to MET gene copy number were similar. With a median follow-up duration of 26.4 months (range, 2.6-73.2 months), the estimated 3-year relapse-free survival and overall survival rates were 54.3% and 77.4%, respectively. No significant association was observed between the MET gene copy number and survival in a multivariate analysis. The MET gene copy number investigated in this study was not found to be associated with prognosis in patients with curatively resected gastric cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Neoplasias Gástricas
/
Projetos Piloto
/
Análise Multivariada
/
Taxa de Sobrevida
/
Seguimentos
/
Cisplatino
/
Quimioterapia Adjuvante
/
Dosagem de Genes
/
Reação em Cadeia da Polimerase em Tempo Real
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Chonnam Medical Journal
Ano de publicação:
2015
Tipo de documento:
Artigo
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