Signaling Pathways in Osteoclast Differentiation / 전남의대학술지
Chonnam Medical Journal
;
: 12-17, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-788330
ABSTRACT
Osteoclasts are multinucleated cells of hematopoietic origin that are responsible for the degradation of old bone matrix. Osteoclast differentiation and activity are controlled by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and the receptor activator of nuclear factor-kappaB ligand (RANKL). M-CSF and RANKL bind to their respective receptors c-Fms and RANK to stimulate osteoclast differentiation through regulation of delicate signaling systems. Here, we summarize the critical or essential signaling pathways for osteoclast differentiation including M-CSF-c-Fms signaling, RANKL-RANK signaling, and costimulatory signaling for RANK.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoclastos
/
Osso e Ossos
/
Matriz Óssea
/
Transdução de Sinais
/
Citocinas
/
Fator Estimulador de Colônias de Macrófagos
/
Ligante RANK
Idioma:
Inglês
Revista:
Chonnam Medical Journal
Ano de publicação:
2016
Tipo de documento:
Artigo
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