Dynamic Regulation of APE1/Ref-1 as a Therapeutic Target Protein / 전남의대학술지
Chonnam Medical Journal
;
: 75-80, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-788343
ABSTRACT
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that plays a central role in the cellular response to DNA damage and redox regulation against oxidative stress. APE1/Ref-1 functions in the DNA base excision repair pathway, the redox regulation of several transcription factors, and the control of intracellular redox status through the inhibition of reactive oxygen species (ROS) production. APE1/Ref-1 is predominantly localized in the nucleus; however, its subcellular localization is dynamically regulated and it may be found in the mitochondria or elsewhere in the cytoplasm. Studies have identified a nuclear localization signal and a mitochondrial target sequence in APE1/Ref-1, as well as the involvement of the nuclear export system, as determinants of APE1/Ref-1 subcellular distribution. Recently, it was shown that APE1/Ref-1 is secreted in response to hyperacetylation at specific lysine residues. Additionally, post-translational modifications such as phosphorylation, S-nitrosation, and ubiquitination appear to play a role in fine-tuning the activities and subcellular localization of APE1/Ref-1. In this review, we will introduce the multifunctional role of APE1/Ref-1 and its potential usefulness as a therapeutic target in cancer and cardiovascular disease.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxirredução
/
Fosforilação
/
Fatores de Transcrição
/
Dano ao DNA
/
DNA
/
Biomarcadores
/
Doenças Cardiovasculares
/
Processamento de Proteína Pós-Traducional
/
Espécies Reativas de Oxigênio
/
Estresse Oxidativo
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Chonnam Medical Journal
Ano de publicação:
2016
Tipo de documento:
Artigo
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