Prevalence of Possible von Willebrand Disease / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 16-22, 2014.
Artigo
em Coreano
| WPRIM
| ID: wpr-788507
ABSTRACT
BACKGROUND:
Definition of possible von Willebrand disease (VWD) included levels of von Willebrand factor antigen (VWFAg) or von Willebrand factor ristocetin cofactor activity (VWFRCo) below 30 U/dL. The purpose of this study was to determine the prevalence of possible VWD in Ulsan, Korea. We also analyzed the influence of demographic factors such as age, gender, and blood group on subject levels of VWF.METHODS:
Between March 2011 and September 2011 we prospectively investigated 1,039 subjects (271 children, 768 adults). Blood samples were collected for the determination of VWFAg, VWFRCo, and factor VIII coagulation assay (FVIIIC). A standardized questionnaire was administered to evaluate hemorrhagic symptoms at the time of first examination, using a bleeding score ranging from 0 to 3.RESULTS:
Forty five subjects met the criteria for possible VWD, for a prevalence of 4.3%. Subjects of Group O had a significantly lower mean FVIIIC, VWFAg, and VWFRCo value than subjects of group A,B, or AB (P<0.001).CONCLUSION:
Our results suggest that the prevalence of VWD may be much higher than previously reported. Efforts to increase the awareness and diagnosis of VWD may help improve identification of patients with bleeding disorders and lead to early, appropriate management with safe and efficacious therapies.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças de von Willebrand
/
Fator VIII
/
Fator de von Willebrand
/
Demografia
/
Prevalência
/
Estudos Prospectivos
/
Inquéritos e Questionários
/
Diagnóstico
/
Hemorragia
/
Coreia (Geográfico)
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
Limite:
Criança
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Clinical Pediatric Hematology-Oncology
Ano de publicação:
2014
Tipo de documento:
Artigo
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