A Case of Thrombotic Microangiopathy Following Autologous Stem Cell Transplantation / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
; : 140-144, 2014.
Article
em En
| WPRIM
| ID: wpr-788518
Biblioteca responsável:
WPRO
ABSTRACT
Transplantation-associated thrombotic microangiopathy (TA-TMA) is an uncommon but devastating complication in patients who undergo hematopoietic stem cell transplantation (SCT). However, the optimal treatment strategy for TA-TMA is unclear. We report a rare case of TA-TMA in a 39-month-old boy who underwent tandem autologous SCT (autoSCT) for high-risk medulloblastoma. TA-TMA developed 64 days after the second autoSCT with microangiopathic hemolytic anemia, fever, renal impairment, acute respiratory distress syndrome and posterior reversible encephalopathy syndrome. The patient recovered after plasmapheresis and methylprednisolone therapy. He had mild to moderate deficiency of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS-13). The patient's clinical course would suggest that plasmapheresis and methylprednisolone therapy could be a treatment option for TA-TMA. Early intervention is needed to aid the recovery of the patient who is suspected for TA-TMA.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Pediatria
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Síndrome do Desconforto Respiratório
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Metilprednisolona
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Plasmaferese
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Transplante de Células-Tronco Hematopoéticas
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Intervenção Educacional Precoce
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Trombospondinas
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Transplante de Células-Tronco
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Síndrome da Leucoencefalopatia Posterior
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Microangiopatias Trombóticas
Limite:
Child, preschool
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Humans
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Male
Idioma:
En
Revista:
Clinical Pediatric Hematology-Oncology
Ano de publicação:
2014
Tipo de documento:
Article