Expression of Bradykinin Receptors and Effects of Bradykinin in the Interstitial Cells of Cajal from Mouse Small Intestine / 체질인류학회지
Korean Journal of Physical Anthropology
; : 289-295, 2004.
Article
em Ko
| WPRIM
| ID: wpr-78858
Biblioteca responsável:
WPRO
ABSTRACT
Interstitial Cells of Cajal (ICC) are pacemaker cells that generates slow waves and drive spontaneous mechanical contractions of gastrointestinal smooth muscle. Slow waves are generated the periodic activation of spontaneous inward currents (pacemaker currents). We studied the modulation of pacemaker activities by bradykinin (10-8 M) in cultured ICC with the whole cell patch-clamp technique, and the localization of bradykinin-2 receptor-immunoreactivity using double labelling immunohistochemistry in the murine small intestine. Externally applied bradykinin produced membrane depolarization in current-clamping mode. At a -70 mV of holding potential bradykinin increased tonic inward pacemaker currents. Double labelling with bradykinin-2 receptor and and c-kit was shown that ICC expressed the bradykinin-2 receptor-immunoreactivity. These results suggest that bradykinin modulates electrical activities of ICC via bradykinin-2 receptor, which may regulate gastrointestinal motility.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Bradicinina
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Imuno-Histoquímica
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Receptores da Bradicinina
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Técnicas de Patch-Clamp
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Células Intersticiais de Cajal
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Motilidade Gastrointestinal
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Intestino Delgado
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Membranas
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Músculo Liso
Limite:
Animals
Idioma:
Ko
Revista:
Korean Journal of Physical Anthropology
Ano de publicação:
2004
Tipo de documento:
Article