Advances in molecular mechanisms for enhanced hepatic lipogenesis in insulin resistance / 药学学报

ABSTRACT

Hepatic selective insulin resistance refers to that insulin fails to suppress hepatic glucose production but continues to promote hepatic lipogenesis in insulin resistance. Therefore, type 2 diabetes mellitus is characterized with dyslipidemia apart from hyperglycemia. This review highlights the roles and molecular mechanisms of the key hepatic lipogenesis factors such as sterol regulatory factor binding protein 1c (SREBP1c), mammalian rapamycin target complex 1 (mTORC1), endoplasmic reticulum stress (ER stress), FoxO1, lipid synthesis substrate, etc.