tients with chronic heart failure / 心血管康复医学杂志

ABSTRACT

Objective:To study influence of exercise rehabilitation on serum levels of N terminal pro brain natriuretic peptide (NT‐proBNP) and high sensitive cardiac troponin T (hscTnT) and cardiac function indexes in patients with chronic heart failure (CHF).Methods:A total of 140 CHF patients treated in our hospital were randomly and equal‐ly divided into routine group (received routine treatment ) and exercise rehabilitation group (received exercise reha‐bilitation based on routine group ) ,both groups were treated for three weeks .Serum levels of NT‐proBNP ,hscTnT and cardiac function indexes were measured and compared between two groups before and after rehabilitative inter‐vention .Results:Compared with routine group after three‐week treatment ,there were significant reductions in ser‐um levels of NT‐proBNP [ (2. 60 ± 0. 53) μg／L vs.(2. 11 ± 0.52) μg／L] ,hscTnT [ (0.38 ± 0. 12) μg／L vs.(0. 30 ± 0.09) μg／L] ,left ventricular end‐diastolic dimension (LVEDd) [ (56.78 ± 6.21) mm vs.(50. 10 ± 4.21) mm] , left ventricular end‐systolic dimension (LVESd) [ (48. 11 ± 5. 88) mm vs.(35.00 ± 6.20) mm] ,left atrial diameter (LAD) [ (44. 01 ± 5.69) mm vs.(34.26 ± 6.09) mm] and left ventricular mass index (LVMI) [ (185.01 ± 31. 34) g／m2 vs.(125.89 ± 43. 52) g／m2 ] ,and significant rise in LVEF [ (43.10 ± 6.21)% vs.(52.13 ± 5.10)%] and left ventricular early／late diastolic peak flow velocity (E／A) [ (0. 94 ± 0. 44) vs.(1.40 ± 0.56)] in exercise rehabilita‐tion group , P＝0.001 all .Conclusion:Exercise rehabilitation can significantly reduce serum NT‐proBNP and hscTnT levels ,improve cardiac function in CHF patients .