Preparation and in vitro release characterization of hot-melt pressure sensitive ad-hesive transdermal patch of progesterone / 药学实践杂志
Journal of Pharmaceutical Practice
;
(6): 44-47, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-790554
ABSTRACT
Objective To prepare hot‐melt pressure sensitive adhesive (HMPSA) transdermal patches of progesterone and investigate the release characterization in vitro .Methods SIS HMPSA was used as matrix material ,modified Franz diffu‐sion cell and excised female rat skin were used as model ,the concentration of progesterone was determined by HPLC .The thickness of patch and penetration enhancers was screened out by permeation rate .Results 2% IPM was used to prepare pro‐gesterone HMPSA transdermal patch ,thickness was 300 μm ,the cumulative permeation curve was Q=6 .172 1 t-5 .457 7 (r=0 .998 8) .The cumulative releases of the patches in 24 h was 144 .17 μg/cm2 . The permeation rate was (6 .17 ± 0 .49)μg/(cm2 · h) .Conclusion The progesterone HMPSA transdermal patch had good transdermal release in vitro ,which would have good clinical application prospect .
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
Journal of Pharmaceutical Practice
Ano de publicação:
2016
Tipo de documento:
Artigo
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