Advances of validation of bioactive small molecule targets / 药学实践杂志
Journal of Pharmaceutical Practice
;
(6): 97-102, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-790567
ABSTRACT
With the development of science and the progress of age,medicinal chemistry is not only limited to the lead discovery and the structure-activity relationship studies,but also finding the target of bioactive small molecule drugs has be-come a tough issue to be solved.The identification and validation of bioactive small molecule targets has become the most criti-cal and difficult task,which plays a decisive role in academic and pharmaceutical research.Herein we summarize the current methods for target identification of small molecules,and mainly discuss about the target identification method by the chemical probes.Recent cases of successful application were also introduced to demonstrate the strategy of probe synthesis and design.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Journal of Pharmaceutical Practice
Ano de publicação:
2016
Tipo de documento:
Artigo
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