Predicting expiration date of torasemide injection by classical constant-tempera-ture experiment / 药学实践杂志

ABSTRACT

Objective To investigate the stability of torasemide injection and predict its expiration date in room temperatue .Methods The contents of torasemide were determined by HPLC .The expiration date was predicted by classical constant-temperature experiment .Results The contents of torasemide degradation with time according to a first order reaction at room temperature (25 ℃) .The disintegration rate constant K was K25 ℃ =5 .186 9 × 10-6 h-1 and the expiration date of to-rasemide injection was t0 .9 =2 .32 years .Conclusion The torasemide injection expiration date was tentatively scheduled for two years .