Distribution of common pathogens and resistance analysis in a tertiary hospital / 药学实践杂志

ABSTRACT

Objective To analyse the distribution of main pathogens and drug resistance in a tertiary hospital during 2014 ,and to provide the reference for the clinical rational use of antimicrobial agents .Methods Conventional methods were used for bacterial culture ,VITEK-2 automatic detection system of French BioMerieux company was used for bacteria identifica-tion ,and bacterial resistance analysis ,and WHO NET 5 .5 software was used for data analysis .Results Gram negative bacte-ria accounted for 78 .09% ;Gram positive bacteria accounted for 21 .91% .K lebsiella pneumoniae detection rate was the high-est ,that is 16 .07% ,followed by EscherichiaColi (12 .75% ) ,Bauman Acinetobacter (12 .69% ) and Pseudomonas aeruginosa (10 .91% ) .The resistant rate of methicillin resistant Staphylococcus aureus(MRSA)was 42 .8% (101) ,and the resistant rate of methicillin resistant coagulase negative staphylococci (MRCNS) was 75 .62% (152) .Resistant rates of Staphylococcus au-reus ,both coagulase negative staphylococcus and enterococcus faecalis to vancomycin and linezolid were zero .Resistant rates of enterococcus faecium to vancomycin and linezolid were 5 .5% and zero respectively .Pathogens were detected mainly in emer-gency department ,and the main pathogens were widely distributed .Conclusion Conducting monitoring of bacterial drug re-sistance and grasping the change trend of drug resistance have important significance to guide clinical rational drug use .