Studies on the binding properties of Zn2+ ion to quercetin and the antioxidant ac-tivi ties / 药学实践杂志
Journal of Pharmaceutical Practice
;
(6): 50-54, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-790832
ABSTRACT
Objective To study the anti-oxidation properties of Zn2+-quercetin complexes .Methods The binding stoi-chiometric ratios and the binding constant of Zn2+ to quercetin were measured with UV-Vis spectroscopy .The binding sites on quercetin were determined via1 H NMR spectroscopy .The antioxidant activities of Zn2+-quercetin complexes were compared to quercetin by scavenging DPPH radical method .The binding ratio of Zn2+ to quercetin depends on neutralization of phenol groups of quercetin .Results The binding ratio of Zn2+ to quercetin is 12 when less than two OH groups were deprotonated . The binding ratio is 11 when more than three OH groups were deprotonated .The apparent binding constant is 2 .42 × 106 M -1 for the 11 Zn2+-quercetin complex .The 3′-OH and 4′-OH of quercetin are involved in the Zn2+ binding .The scavenging DPPH radical activity of Zn2+-quercetin complex is 2 .3 times of quercetin .Conclusion These results provide a new insight to expand applications of this traditional Chinese medicine .
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Pharmaceutical Practice
Ano de publicação:
2018
Tipo de documento:
Artigo
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