Relationship between dietary calorie structure and dementia in middle?aged and elderly women / 中华健康管理学杂志

ABSTRACT

Objective To study the relationship between dietary calorie structure and dementia in middle?aged and elderly women. Methods Data for the present study were obtained from the Study of Women's Health Across the Nation(SWAN). Dietary intake was estimated using the 1995 Dietary Frequency Questionnaire. Mann?Whitney U test was used to compare the difference of mean values between the two groups. Logistic regression analysis was used to assess the relationship between dietary calorie structure and dementia. Restricted cubic spline analysis was used to examine if there was a non?linear relationship between them. Results The racial composition of the dementia group was significantly different from that of the control group(χ2=32.720, P<0.001). The serum triglyceride level in the dementia group was significantly higher than that in the control group(Z=-1.966, P=0.049). The daily intake of protein calories in the dementia group was lower than that in the control group(control group 15.70%(13.39%-17.96%), dementia group 15.18%(13.02%-17.52%), Z=-3.521, P<0.001), while the sweet calories in dementia group were higher than those in the control group(control group 12.15%(6.38%-21.31%), dementia group 14.09%(6.38%-21.31%), Z=-3.521, P=0.001). In the unadjusted model, protein calorie and alcohol calorie were inversely correlated with dementia, OR and 95% CI were 0.961%(0.939%-0.983%) and 0.983(0.965-1.000), respectively. Sweet calories were positively correlated with dementia risk, OR and 95% CI were 1.010(1.003-1.017). This relationship persisted after adjusting for age. After adjusting the age, race, and TG of the confounding factors, the relationships of protein calorie and sweet calorie with dementia remained intrinsic after adjusting the confounding factors adequately; the OR and 95% CI were 0.966(0.943-0.989) and 1.010(1.003-1.016), respectively. Restricted cubic spline regression showed that the risk of dementia decreased rapidly and then stabilized with the increase of protein calorie proportion. With the increase of the proportion of sweets in calories, the risk of dementia first increased rapidly, then slowed down, and then decreased. The risk of dementia increased rapidly with the increase in sweetener/protein calories, and then reached plateau stage. Conclusions This study found a negative correlation between the proportion of protein calories in the daily diet and the risk of dementia. Sweet calories were positively correlated with dementia risk. However, as this was a cross?sectional study, the causal relationship between protein and sweet intake and dementia could not be determined.