Regulatory effects of IL-33/ST2 axis on adipose tissue immune cells and relationship to obesity / 中华微生物学和免疫学杂志

ABSTRACT

Obesity is a health problem of great concern to the whole society. Numerous studies have shown that obesity can lead to changes in the types and numbers of immune cell subsets and immune molecules in visceral adipose tissues, and IL-33/ST2 plays a crucial role in maintaining immune homeosta-sis. This paper reviewed the regulatory effects of IL-33/ST2 on adipocytes and immune cells in adipose tis-sues, as well as the changes of IL-33 in adipose tissues and the whole body during obesity in recent years.