The Characteristics of Incidental Pituitary Microadenomas in 120 Korean Forensic Autopsy Cases
Journal of Korean Medical Science
;
: S61-S65, 2007.
Artigo
em Inglês
| WPRIM
| ID: wpr-79230
ABSTRACT
To investigate the characteristics of incidental pituitary microadenomas, we examined 120 pituitary glands from Korean forensic autopsy cases, from which eight tumors were identified (incidence 6.7%). The average age of the affected subjects was 50 yr (range 33-96 yr) with a female predominance. The maximum diameters of the tumors ranged from 0.4 to 5.4 mm (mean 2.8 mm). Immunohistochemical analysis of pituitary hormones revealed three growth hormone-secreting adenomas, one prolactin-producing adenoma, one gonadotropin-producing adenoma, one plurihormonal adenoma, and two null cell adenomas. MIB-1 staining for Ki-67 antigen showed no positive expression. The microvessel density (MVD) of the pituitary microadenomas ranged from 2.3 to 11.6% (mean 5.3%) and was significantly lower than that of nonneoplastic pituitary glands (11.9-20.1%, mean 14.8%). Our study provides reference data on incidental pituitary microadenomas in the Korean population.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Hormônios Hipofisários
/
Neoplasias Hipofisárias
/
Autopsia
/
Imuno-Histoquímica
/
Adenoma
/
Antígeno Ki-67
/
Coreia (Geográfico)
/
Microcirculação
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2007
Tipo de documento:
Artigo
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