A study on the association between vitamin D status and ultrasonic bone mineral density among children / 预防医学

ABSTRACT

Objective To evaluate vitamin D nutritional status and its relationship with ultrasonic bone mineral density among children in Wenzhou City.Methods Overnight fasting venous blood samples of 546 children were collected to measure the concentration of serum 25 -hydroxyvitamin D (25 (OH)D),and bone mineral density was measured.Results The average concentration of serum 25 (OH)D was 25. 42 ±0. 590 ng/mL,25. 09% of participants were found with sufficient vitamin D,the rate of severe deficiency,deficiency and insufficiency were 1. 47%,32. 60% and 40. 84%respectively.The concentration of 25 (OH)D in different age groups was statistically significantly different (P<0. 01 ). Vitamin D nutritional status of the older groups was poor than that of the younger ones.In the group of children aged 7 to 1 1 and 11 to 14,the levels of 25(OH)D of boy was significantly higher than that of girl.Compared to those with sufficient vitamin D,children with vitamin D deficiency or insufficiency had lower bone mineral density(BMD)(P<0. 05 ).The level of 25(OH)D was correlated with BMD (r=0. 197,P<0. 01).After adjusted age and BMI,there was still a positive correlation between 25(OH)D level and BMD (r=0. 115,P<0. 01).Conclusions The vitamin D level of children in Wenzhou area is low.The level of serum 25 (OH)D may be related to BMD .More attention should be paid to the supplementation of vitamin D.