An observation on the immune effect of hepatitis B vaccine by different immunization schedules among adults / 预防医学

ABSTRACT

Objective To evaluate the immune effect of hepatitis B vaccine by different immunization schedules among adults,and to provide evidence for developing immunization strategy.Methods Adults aged 1 6 to 49 years with negative HBsAg and anti -HBs in Tongxiang city voluntarily received domestic or imported hepatitis B vaccine.These subjects were divided into 4 groups (Group A:1 0 μg domestic vaccine,0 -1 -3 schedule;group B:1 0 μg domestic vaccine,0 -1 -6 schedule;group C:1 0 μg imported vaccine,0 -1 -3 schedule;group D:1 0 μg imported vaccine,0 -1 -6 schedule). Quantitative detection of anti -HBs was conducted in 1 month and 1 year,and the anti -HBs positive rate and geometric mean titers of anti -HBs (GMT)were evaluated.Results A total of 848 subjects were evaluated.The anti -HBs positive rate was 99.76% after immunization in 1 month,and no significant differences were observed among different groups (P >0.05).The GMT of anti -HBs in group A was significantly lower than that of group C and B (P <0.05),while no significant differences were observed among group B and D.The GMT of anti -HBs was significantly decreased with ages. The anti -HBs positive rate was 70.28% after immunization in 1 year,which was significantly lower than that in 1 month after immunization.Conclusion Better immune effect could be achieved by 1 0 μg domestic hepatitis B vaccine with 0 -1-3 schedule.