Genetic Diversity and Exotoxin A Production of Group A Streptococci Causing Sepsis
Journal of Korean Medical Science
;
: 193-198, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-79365
ABSTRACT
The M protein and streptococcus pyrogenic exotoxin (SPE A) are important virulence factors in group A streptococci (GAS) infections. The emm types of GAS strains isolated from patients with sepsis were determined by sequencing the 5' N-terminus of the emm gene, encoding the M protein, and clonality analysis using pulsed-field gel electrophoresis. The presence of speA and production of SPE A were also examined. There were no predominant GAS clones. The emm genotypes were variable, and the most common genotype was emm13 (17.9%). The production prevalence of SPE A was 21.4%. The low mortality rate (7.1%) of GAS sepsis might be attributable to the low incidence of virulent strains such as emm1 (10.7%) and emm3 (7.1%), as well as to low production rate of SPE A.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Infecções Estreptocócicas
/
Streptococcus pyogenes
/
Proteínas de Bactérias
/
Variação Genética
/
Virulência
/
DNA Bacteriano
/
Sepse
/
Exotoxinas
/
Genótipo
/
Proteínas de Membrana
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2006
Tipo de documento:
Artigo
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