Anti-inflammatory effects of a Houttuynia cordata supercritical extract
Journal of Veterinary Science
;
: 273-275, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-79609
ABSTRACT
Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in a carrageenan-air pouch model. HSE (200 mg/kg, oral) suppressed exudation and albumin leakage, as well as inflammatory cell infiltration. Dexamethasone (2 mg/kg, i.p.) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content. HSE lowered tumor-necrosis factor (TNF)-alpha and nitric oxide (NO), as well as prostaglandin E2 (PGE2). Dexamethasone only reduced TNF-alpha and NO, while indomethacin decreased TNF-alpha and PGE2. The suppressive activity of HSE on NO and PGE2 production was confirmed in RAW 264.7. These results demonstrate that HSE exerts anti-inflammatory effects by inhibiting both TNF-alpha-NO and cyclooxygenase II-PGE2 pathways.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dexametasona
/
Medicamentos de Ervas Chinesas
/
Dinoprostona
/
Transdução de Sinais
/
Carragenina
/
Indometacina
/
Análise de Variância
/
Técnicas Imunoenzimáticas
/
Fator de Necrose Tumoral alfa
/
Linhagem Celular Tumoral
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of Veterinary Science
Ano de publicação:
2010
Tipo de documento:
Artigo
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