Neutrophil to lymphocyte ratio and monocyte to lymphocyte ratio in early pregnant women with hypertensive disorders / 中华全科医师杂志

ABSTRACT

Objective@#To investigate the correlation of systemic inflammation parameters including neutrophil to lymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR) with the pregnancy outcome of hypertension disorders of pregnancy.@*Methods@#Two hundred and twelve pregnant women in first-trimester with hypertensive disorders and 212 matched healthy subjects (control group) were enrolled in the study. The differences in white blood cell count (WBC), neutrophil (N), lymphocyte (L), monocyte (M), NLR and MLR were compared between groups.@*Results@#The WBC, N, M, NLR and MLR values were significantly higher in pregnant women with hypertensive disorders than those in healthy controls (9.1×109/L vs.8.5×109/L,Z=4.89, P<0.01; 6.6×109/L vs. 5.9×109/L,Z=4.33, P<0.01; 0.5×109/L vs. 0.4×109/L,Z=3.83, P=0.01; 3.7 vs. 3.3, Z=1.97, P=0.04; 0.3 vs. 0.2, Z=3.83, P=0.01). The pregnant women were divided into gestational hypertension group (n=48), mild and severe preeclampsia group (n=77), chronic hypertension with superimposed preeclampsia group (n=55) and chronic hypertension complicating pregnancy group (n=32). There were no significant differences in the WBC, N, L, M,NLR and MLR values among all groups (P>0.05). Multivariate logistic regression analysis showed that NLR was a predictive factor of hypertensive disorders of pregnancy (OR=1.68, 95%CI 1.07-2.62, P<0.05).@*Conclusions@#NLR might be a useful systemic inflammation marker for the prediction of hypertensive disorders in women with early pregnancy.