Relationship between serum CRTC3 and insulin resistance in patients with type 2 diabetes mellitus and abdominal obesity / 中华内分泌代谢杂志

ABSTRACT

To detect serum cAMP-responsive element-binding protein-regulated transcription coactivator 3 (CRTC3) level in subjects with type 2 diabetes mellitus and abdominal obesity and to investigate the relationship of serum CRTC3 level with glycolipid metabolism and insulin resistance. One hundred and seventy patients with type 2 diabetes (T2DM group) and 80 normal controls (NC group) were recruited in the study. They were divided into non-abdominal obesity (NAO) and abdominal obesity (AO) subgroup. Abdominal obesity was defined as waist circumference ≥90 cm in men and ≥85 cm in women. Body fat parameters were measured and body mass index, waist-to-hip ratio were determined. Fasting blood glucose (FBG), 2 h postload blood glucose (2hBG), lipids, HbA1C, fasting insulin, fasting C-peptide, CRTC3, and adiponectin were also detected. Insulin resistance and pancreas β cell function were assessed by modified homeostasis model assessment for insulin resistance (HOMA-IR) and β cell function (HOMA-β). Bivariate correlation analysis showed that serum CRTC3 level was positively correlated with waist circumference, body mass index, waist-to-hip ratio, systolic blood pressure, diastolic blood pressure, FBG, 2hBG, HbA1C, total cholesterol, triglyceride, fasting C-peptide, and HOMA-IR (P<0.05 or P<0.01), and was negatively correlated with high density lipoprotein-cholesterol, adiponectin, and HOMA-β (P<0.05). Multivariate linear regression analysis showed that waist-to-hip ratio, adiponectin, total cholesterol, FBG, and HOMA-IR were independently related to serum CRTC3 level (P<0.05 or P<0.01). Serum CRTC3 level was increased in patients with type 2 diabetes as well as in abdominal obesity, and was closely related with glycolipid metabolism, adiponectin, and insulin resistance.