Clinicopathological analysis of 12 cases of children synovial sarcoma / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 705-709, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-797838
ABSTRACT
Objective@#To investigate histopathological characteristics, and differential diagnoses of childhood synovial sarcoma.@*Methods@#HE staining, immunohistochemical staining and fusion gene detection by FISH were performed in 12 cases of synovial sarcoma in childhood at Beijing Children′s Hospital from 2016 to 2018.@*Results@#There were 6 cases of biphasic type, 1 case of monophasic epithelial type, 3 cases of monophasic spindle cell type and 2 cases of poorly differentiated synovial sarcomas. EMA, CKpan, bcl-2, CD99, TLE1 and CD34 immunostain positivities were observed in 10/12, 9/12, 12/12, 10/12, 10/12 and 0/12 cases respectively. Unique INI1 immunohistochemical staining was observed in 9/12 cases. SS18-SSX gene fusion was detected in 8 of 11 cases by FISH.@*Conclusions@#Synovial sarcoma is rare in children. Histological morphology combined with immunohistochemistry and FISH SS18-SSX fusion gene detection are important for the diagnosis and differential diagnosis of synovial sarcoma in children.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Pathology
Ano de publicação:
2019
Tipo de documento:
Artigo
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