γ-Secretase mutations in acne inversa / 中华皮肤科杂志
Chinese Journal of Dermatology
; (12): 656-659, 2019.
Article
em Zh
| WPRIM
| ID: wpr-797852
Biblioteca responsável:
WPRO
ABSTRACT
Acne inversa is a chronic inflammatory skin disease of the folliculo-sebaceous-apocrine unit. Currently, genetic and immunological factors are hot topics in the study of its pathogenesis. Genetic factors are mainly related to γ-secretase mutations, and abnormal expression of the γ-secretase-Notch axis leads to increased keratinization of hair follicles and inflammation in some patients with haploinsufficiency of the γ-secretase gene. Mutations in the γ-secretase gene are not necessary for acne inversa, and the risk of Alzheimer′s disease in familial acne inversa patients still remains unclear. Some progress has been made in researches on the association of genotype with phenotype in acne inversa patients, but further studies with large sample size are needed for verification.
Texto completo:
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Dermatology
Ano de publicação:
2019
Tipo de documento:
Article