Research progress of circadian rhythm and reperfusion therapy in wake-up stroke / 中华神经科杂志

ABSTRACT

Wake-up stroke (WUS) is clinically defined as ischemic stroke that is associated with neurological deficits on awakening, accounting for approximately one in five individuals presenting with an acute ischemic stroke. At present, the mechanism of WUS onset is still unclear, and whether circadian mechanisms are involved deserves further exploration. Previously, these patients were missed the opportunity of reperfusion therapy due to unknown onset time. Recent studies have changed this concept. Intravenous thrombolysis or mechanical thrombectomy can be performed in appropriate patients after imaging evaluation, thus improving the prognosis of some patients with WUS. This article summarizes the latest research in recent years.