Multiple myeloma with lung cancer: 3 cases and literature review / 中国基层医药

ABSTRACT

Objective@#To report 3 cases of multiple myeloma (MM) with lung cancer.Combined with literature review to improve the understanding of MM with lung cancer.@*Methods@#The clinical characteristics, treatment and prognosis of 3 cases of MM with lung cancer in Shijingshan Teaching Hospital of Capital Medical University from January 2017 to December 2018 and the relevant literature were retrospectively reviewed.@*Results@#Among the 3 patients, 2 cases were male and 1 case was female, with an average age of 69.7 years.The pathological type of lung cancer patients was adenocarcinoma, of which 2 cases were positive for EGFR gene mutation and 1 case was positive for ALK fusion gene.Three cases of multiple myeloma were all IgG-kappa light chain type, with stage Ⅲ A. The chemotherapy regimens used in MM patients were all PD regimen 4-6 cycles; one patient died of pulmonary infection, one patient had MM CR, but lung cancer progressed, one patient had MM very good partial remission (VGPR), and there was no recurrence of lung cancer.@*Conclusion@#The pathogenesis of second primary malignancy in MM is not clear, which needs further study.