Progress of astrocytes and their exosomes in central nervous system disease / 国际儿科学杂志

ABSTRACT

Astrocytes exist in the central nervous system widely, through cell-cell communication in neurovascular units, playing an important role in providing metabolic support for neurons, regulating nerve function and plasticity and so on.There is evidence that exosomes play a key regulatory role in intercellular communication by carrying natural cargo molecules and participate in a variety of pathophysiological processes.However, the role of astrocyte-derived exosome in central nervous system diseases is largely unknown.In this paper, the classification, characteristics, biomarkers, physiological functions, functions of astrocyte-derived exosome and their roles in central nervous system diseases are reviewed, for a deeper understanding of the role of astrocytes in central nervous system diseases.