Progress of JAK-STAT pathway in the angiogenesis of glioma / 肿瘤研究与临床

ABSTRACT

Vascular nutrition transmission is an irreplaceable factor in the process of tumor formation. Blocking or reducing the energy transmission pathway of tumor can effectively resist the development of tumor. There is a close relationship between JAK-STAT signaling pathway and angiogenesis, especially research on the relationship between this pathway and vascular endothelial growth factor (VEGF) signal has produced many results in recent years. This review summarizes the induction of angiogenesis, drug development, and the discovery of antiangiogenic targets in the JAK pathway, providing some ideas for the treatment of glioma.