Efficacy and safety of Yangzheng Xiaoji capsule combined with radiotherapy and chemotherapy in the treatment of gastric cancer and its influence on immune function / 中国基层医药

ABSTRACT

Objective@#To explore the efficacy and safety of Yangzheng Xiaoji capsule combined with radiotherapy and chemotherapy in the treatment of gastric cancer and its influence on immune function.@*Methods@#From October 2016 to October 2018, 80 patients with gastric cancer in the First People's Hospital of Yongkang were divided into two groups according to the random number table, with 40 cases in each group.The control group received conventional radiotherapy plus chemotherapy, namely oxaliplatin, 5-fluorouracil combined with calcium leucovorin conventional chemotherapy.The observation group received Yangzheng Xiaoji capsule on the basis of the control group.The clinical symptoms, objective tumor efficacy, TCM symptoms and signs score, safety, immune function of the two group were observed.@*Results@#The total effective rate of the observation group was 87.5%, which was significantly higher than 72.5% of the control group(χ2=3.52, P<0.05). The RR, DCR of the observation group were 62.5%, 87.5%, respectively, which were significantly higher than 30.0%, 72.5% of the control group(χ2=4.31, P<0.05). The TCM symptoms and signs scores of the two groups after treatment were significantly improved compared with those before treatment(all P<0.05), which of the observation group after treatment was significantly lower than that of the control group(t=5.13, P<0.05). There were no statistically significant differences in WBC, Hb and PLT of the observation group before and after treatment(t=1.24, 1.62, 1.37, all P>0.05), and there were statistically significant differences in WBC, Hb and PLT of the control group before and after treatment(t=4.85, 3.64, 3.85, all P<0.05), and the WBC, Hb and PLT of the observation group were significantly higher than those of the control group after treatment(t=6.37, 4.15, 5.27, all P<0.05). In the observation group, leukopenia decreased in 4 cases, hemoglobin decreased in 6 cases and transaminase increased in 6 cases, which were significantly lower than 8 cases, 10 cases and 10 cases in the control group (χ2=4.26, P<0.05). Before treatment, there were no statistically significant differences in the levels of CD3＋, CD4＋, CD8＋, CD4＋/CD8＋ between the two groups(all P>0.05). There were no statistically significant differences in the levels of CD3＋, CD4＋, CD8＋, CD4＋/CD8＋ of the observation group before and after treatment(t=2.14, 2.08, 1.69, 2.47, all P>0.05), and compared with before treatment, the levels of CD3＋, CD4＋, CD4＋/CD8＋ of the control group were significantly decreased(t=5.12, 4.26, 5.38, all P<0.05), while the level of CD8＋ was significantly increased(t=3.86, P<0.05). After treatment, the levels of CD4＋, CD4＋, CD8＋, CD4＋/CD8＋ of the observation group were significantly better than those of the control group (t=4.79, 3.52, 4.28, 3.61, all P<0.05).@*Conclusion@#Yangzheng Xiaoji capsule combined with radiotherapy and chemotherapy can improve the curative effect of patients with gastric cancer, and it has high safety, less toxic and side effects, and can improve the immune function of patients with gastric cancer.It is worthy of promoting.