Analysis of pathogen distribution and drug resistance of pediatric purulent meningitis / 中国基层医药

ABSTRACT

Objective@#To explore the bacteriological characteristics and bacterial resistance of children with purulent meningitis in the Shenmu Hospital, and to provide evidence for the rational use of antibiotics.@*Methods@#We retrospectively analyzed the clinical data and bacterial culture results of 43 children with purulent meningitis in our hospital from June 2009 to March 2017.@*Results@#There were 21 types of bacteria culture and drug susceptibility test Gram-positive bacteria in 16 cases(76.19%), Gram negative bacilli in 5 cases(23.81%), including 8 staph infections, gambogic/lira micrococcus in 4 cases, excrement enterococcus in 1 case, streptococcus pneumoniae in 2 cases, produce mononuclear listeria in 1 case.All the Gram-negative bacilli were Escherichia coli.In cerebrospinal fluid culture, Gram-positive bacteria were significantly higher than Gram-negative bacteria, and the difference was statistically significant(χ2=7.813, P=0.005). There was no statistically significant difference in the number of Gram-positive cases between cerebrospinal fluid and blood culture pathogens(χ2=0.075, P=0.78). Gram positive coccus was generally resistant to penicillin, erythromycin and clindamycin, generation 1 cephalosporin antibiotic, including pneumococcal resistance rate was 100.0%, coagulase negative staphylococcus resistance rate was 87.5%, E.coli was resistant to ampicillin and levofloxacin.@*Conclusion@#In the pediatric treatment of our hospital, coagulase negative staphylococcus aureus and vine/Lila micrococcus is the important pathogenic bacteria that causes the children purulent meningitis, Escherichia coli is the only pathogenic bacteria of the Gram-negative bacterial meningitis.Vancomycin and linezolide are sensitive to cocci, and Escherichia coli is sensitive to antibiotics in the second and third generation of cephalosporins.