Distribution of serum creatinine and establishment of reference interval in healthy adults of Lianyungang, Jiangsu province / 中国基层医药

ABSTRACT

Objective@#To preliminarily establish the reference interval for serum creatinine in healthy adults aged 20-79 years in city of Lianyungang.@*Methods@#A total of 34 577 cases of reference individuals were selected from physical examination population by using the principle of complete randomization, and the concentration of serum creatinine was detected by AU5821 automatic biochemical analyzer with its matching reagents.According to the standards of CLSI C28-A3 and WS/T 402-2012 " Clinical Laboratory Test Project Reference Interval Formulation" , the reference interval of serum creatinine was established.@*Results@#There was statistically significant difference of serum creatinine in gender and age between healthy adults in this area (male group 78[72-84]μmol/L, female group 61[56-66]μmol/L; aged 20-59 of male group 78[72-84]μmol/L, aged 60-79 of male group 77[70-85]μmol/L; aged 20-59 of female group 60[56-65]μmol/L, aged 60-79 of female group 63[58-69]μmol/L) (Z=120.93, Z=31.53, Z=28.45; all P<0.05). Therefore, the reference interval of serum creatinine was established based on gender and age, and its reference interval was 61-97μmol/L (aged 20-59 of male), 60-106μmol/L (aged 60-79 of male), 47-76μmol/L (aged 20-59 of female) and 49-86μmol/L (aged 60-79 of female), respectively.@*Conclusion@#Establishment of reference interval in serum creatinine plays an important role in the auxiliary diagnosis, progression and prognosis evaluation of various kidney diseases.